The present disclosure provides methods for forming flow plate and frame assemblies that comprise an anode frame member, a flow plate, and a cathode frame member with the flow plate retained between the anode and cathode frame members. The present disclosure also provides for flow plate and frame assemblies, fuel cell stacks containing a plurality of the flow plate and frame assemblies, and fuel cell systems containing the fuel cell stacks. A fluidly connected anode fluid pathway can be provided from an anode fluid inlet, through conduits in the anode frame member, onto an anode surface of the flow plate, and into anode flow channels.