A system described herein may provide a technique for the proactive failover of groups of Virtualized Network Functions (“VNFs”) based on monitoring Key Performance Indicators (“KPIs”) associated with the VNFs. KPIs associated with a particular VNF or a set of VNFs may be monitored, and a failover event indicating service degradation or imminent service degradation may be detected based on the KPIs associated with the particular VNF or set of VNFs. Additional VNFs, associated with the particular VNF or set of VNFs, may be further identified for failover from a first data center to a second data center. The additional VNFs may be identified for failover without necessarily monitoring KPIs associated with the additional VNFs, and/or based on factors in addition to KPIs associated with the additional VNFs. For example, the additional VNFs may be failed over based on the KPIs associated with the particular VNF or set of VNFs.