Systems and methods for providing resilient persistent connections for communication are disclosed. Methods include identifying, at a first device, a second device registered with a client connection service; obtaining, from the client connection service, a first resource identifier for delivering request messages to the second device via the client connection service; identifying, based on the obtained first resource identifier, a first target resource for a first request message directed to the second device, wherein the first target resource specifies a first host included in the client connection service; sending, to the client connection service via the data communication network, the first request message to the first target resource for delivery to the second device by the client connection service; and receiving, from the client connection service via the data communication network, a first response message provided by the second device as a response to the first request message.