Provided is a smart medicine case unit including: a main case having an accommodation space to store a component therein; a medicine case accommodated in the accommodation space of the main case, the medicine case including a plurality of medicine compartments that are partitioned to separately accommodate various types of medicine and respectively include light-transmitting holes through which light is transmitted; a circuit board arranged between the medicine case and the main case, wherein an optical sensor provided at a position corresponding to each of the light-transmitting holes and a communication device configured to transmit a signal sensed by the optical sensor to a mobile terminal such as a smartphone are mounted on the circuit board; and a top cover rotatably coupled to the main case to selectively open and close the medicine compartments of the medicine case by a rotational motion.