Invention Grant
- Patent Title: 3D vascularized human ocular tissue for cell therapy and drug discovery
-
Application No.: US16347939Application Date: 2017-11-08
-
Publication No.: US11458225B2Publication Date: 2022-10-04
- Inventor: Kapil Bharti , Min Jae Song , Russell Louis Quinn
- Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US MD Bethesda
- Assignee: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US MD Bethesda
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2017/060666 WO 20171108
- International Announcement: WO2018/089515 WO 20180517
- Main IPC: A61L27/38
- IPC: A61L27/38 ; A61L27/18 ; A61L27/24 ; A61L27/52 ; C12N5/079 ; C12N5/077 ; C12N5/071 ; A61L27/58 ; A61L27/56
Abstract:
Methods are disclosed for fabricating a three-dimensional engineered blood retinal barrier (BRB) comprising a choroid and retinal pigment epithelial cells. The methods include the use of bioprinting. Also disclosed is a three-dimensional engineered BRB, and its use. Methods are also disclosed for using the three-dimensional engineered BRB, such as for the treatment of retinal degeneration in a subject or screening. A three-dimensional printing insert that is adapted for bioprinting on a culture substrate sheet that is securely retained within and exposed through a printing frame is also disclosed.
Public/Granted literature
- US20190290803A1 3D VASCULARIZED HUMAN OCULAR TISSUE FOR CELL THERAPY AND DRUG DISCOVERY Public/Granted day:2019-09-26
Information query
IPC分类:
