Invention Grant
- Patent Title: Compounds, compositions, and methods for treating T-cell acute lymphoblastic leukemia
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Application No.: US16633074Application Date: 2018-07-31
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Publication No.: US11459306B2Publication Date: 2022-10-04
- Inventor: Donald W. Landry , Shi-Xian Deng , Xiaoming Xu , Thomas Diacovo
- Applicant: The Trustees of Columbia University in the City of New York
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Potomac Law Group, PLLC
- International Application: PCT/US2018/044659 WO 20180731
- International Announcement: WO2019/028055 WO 20190207
- Main IPC: C07D403/12
- IPC: C07D403/12 ; C07D239/90 ; A61P35/00 ; A61K31/506 ; A61K31/517 ; A61K31/52 ; A61K31/573 ; C07D401/12 ; C07D403/14 ; C07D473/16

Abstract:
In an aspect, the disclosure provides for compounds (II), compositions, and methods of administering the compounds and compositions to a patient in need thereof. In another aspect, the disclosure relates to compounds and compositions for treating cancer, for example, lymphoid leukemia. The disclosure further provides for compounds which inhibit two phosphoinositide 3-kinase (PI3K) isoforms, y and δ, pharmaceutical compositions comprising said compounds, and methods of using said compounds and pharmaceutical compositions for treatment, amelioration, and/or prevention of non-Hodgkin lymphoma.
Public/Granted literature
- US20200165211A1 Compounds, Compositions, and Methods for Treating T-Cell Acute Lymphoblastic Leukemia Public/Granted day:2020-05-28
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