Invention Grant
- Patent Title: Sulphur substituted 3-oxo-2,3-dihydropyridazine-4-carboxamides
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Application No.: US16765709Application Date: 2018-11-16
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Publication No.: US11459312B2Publication Date: 2022-10-04
- Inventor: Ludwig Zorn , Ulrike Röhn , Ilona Gutcher , Lars Röse , Benjamin Bader , Christina Kober , Rafael Carretero , Detlef Stöckigt , Michael Platten
- Applicant: Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , Deutsches Krebsforschungszentrum
- Applicant Address: DE Leverkusen; DE Berlin; DE Heidelberg
- Assignee: Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft,Deutsches Krebsforschungszentrum
- Current Assignee: Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft,Deutsches Krebsforschungszentrum
- Current Assignee Address: DE Leverkusen; DE Berlin; DE Heidelberg
- Agency: Morrison and Foerster LLP
- Priority: EP17202871 20171121
- International Application: PCT/EP2018/081545 WO 20181116
- International Announcement: WO2019/101642 WO 20190531
- Main IPC: C07D403/04
- IPC: C07D403/04 ; C07D237/14 ; C07D409/12 ; C07D409/14 ; C07D419/14 ; A61P35/00 ; C07D417/14 ; A61K45/06

Abstract:
Disclosed are compounds of general formula (I): wherein R1, R2, A, X, Y and Z are as defined herein, methods of preparing the compounds, intermediate compounds useful for preparing the compounds, pharmaceutical compositions and combinations comprising the compounds and the use of the compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
Public/Granted literature
- US20200299269A1 SULPHUR SUBSTITUTED 3-OXO-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES Public/Granted day:2020-09-24
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