Invention Grant
- Patent Title: Aziridinyl and amino dimeric naphthoquinone compounds and use for acute myeloid leukemia
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Application No.: US16344733Application Date: 2017-10-05
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Publication No.: US11459313B2Publication Date: 2022-10-04
- Inventor: Ashkan Emadi , Rena G. Lapidus , Brandon A. Carter-Cooper , Steven Fletcher , Dana Ferraris , Edward A. Sausville
- Applicant: University of Maryland, Baltimore , MCDANIEL COLLEGE
- Applicant Address: US MD Baltimore; US MD Westminster
- Assignee: University of Maryland, Baltimore,MCDANIEL COLLEGE
- Current Assignee: University of Maryland, Baltimore,MCDANIEL COLLEGE
- Current Assignee Address: US MD Baltimore; US MD Westminster
- Agency: Wolter Van Dyke Davis, PLLC
- Agent Eugene J. Molinelli; Martha Cassidy
- International Application: PCT/US2017/055380 WO 20171005
- International Announcement: WO2018/067842 WO 20180412
- Main IPC: C07D403/10
- IPC: C07D403/10 ; A61P35/02 ; C07C225/30 ; C07D203/14 ; A61K45/06
Abstract:
The invention relates to new amino dimeric naphthoquinone compounds with antileukemic activity. Compounds of the invention demonstrated increased aqueous solubility compared to previously available dimeric naphthoquinones and potent nanomolar inhibition of cell survival in AML cells. Preferred compounds contained an aziridine or a secondary amino alcohol pharmacophore.
Public/Granted literature
- US20200283417A1 AZIRIDINYL AND AMINO DIMERIC NAPHTHOQUINONE COMPOUNDS AND USE FOR ACUTE MYELOID LEUKEMIA Public/Granted day:2020-09-10
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