Invention Grant
- Patent Title: Process for purifying liraglutide
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Application No.: US16829725Application Date: 2020-03-25
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Publication No.: US11459354B2Publication Date: 2022-10-04
- Inventor: Ming-Chih Wu , Hsin-Che Huang , Tsung-Yu Hsiao
- Applicant: SCINOPHARM TAIWAN, LTD.
- Applicant Address: TW Tainan
- Assignee: SCINOPHARM TAIWAN, LTD.
- Current Assignee: SCINOPHARM TAIWAN, LTD.
- Current Assignee Address: TW Tainan
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- Main IPC: C07K1/20
- IPC: C07K1/20 ; C07K14/605

Abstract:
The present invention provides improved processes for purifying liraglutide. Liraglutide is purified via two sequential RP-HPLC purifications followed by a salt-exchange step, where a pH is kept constant in the first and second purification steps. In particular, the processes utilize a halogenated solvent in a sample preparation step, which provides better solubility and an environment suitable for decarboxylation for crude liraglutide prior to a RP-HPLC purification.
Public/Granted literature
- US20200308218A1 PROCESS FOR PURIFYING LIRAGLUTIDE Public/Granted day:2020-10-01
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