Invention Grant
- Patent Title: Anti-IL-2 antibodies and compositions and uses thereof
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Application No.: US16925227Application Date: 2020-07-09
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Publication No.: US11459385B2Publication Date: 2022-10-04
- Inventor: Isaac J. Rondon , Natasha Crellin , Paul Bessette , Eleonora Trotta , Jeffrey A. Bluestone , Lauren K. Ely , Kenan C. Garcia
- Applicant: Pfizer Inc. , The Regents of the University of California , The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US NY New York; US CA Oakland; US CA Stanford
- Assignee: Pfizer Inc.,The Regents of the University of California,The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: Pfizer Inc.,The Regents of the University of California,The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US NY New York; US CA Oakland; US CA Stanford
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C07K16/24
- IPC: C07K16/24 ; A61K39/00
Abstract:
The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
Public/Granted literature
- US20210061902A1 ANTI-IL-2 ANTIBODIES AND COMPOSITIONS AND USES THEREOF Public/Granted day:2021-03-04
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