Invention Grant
- Patent Title: Anti-CD27 and anti-PD-L1 antibodies and bispecific constructs
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Application No.: US16387228Application Date: 2019-04-17
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Publication No.: US11459393B2Publication Date: 2022-10-04
- Inventor: Tibor Keler , Joel Goldstein , Laura A. Vitale , Lizhen He
- Applicant: Celldex Therapeutics, Inc.
- Applicant Address: US NJ Hampton
- Assignee: Celldex Therapeutics, Inc.
- Current Assignee: Celldex Therapeutics, Inc.
- Current Assignee Address: US NJ Hampton
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Jeanne M. DiGiorgio, Esq.
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61P35/00 ; A61K39/00

Abstract:
Provided herein are anti-CD27 and anti-PD-L1 antibodies, and binding domains thereof, as well as bispecific constructs and anti-CD27 binding domain linked to an anti-PD-L1 binding domain. Also provided herein are methods of stimulating T cell activity, methods of inducing or enhancing an immune response, and methods of treating a disease or condition by administering the bispecific constructs, antibodies, or antigen binding fragments thereof, or compositions described herein to a patient in need thereof.
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