Invention Grant
- Patent Title: Bispecific antibodies having constant region mutations and uses therefor
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Application No.: US16065917Application Date: 2016-12-28
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Publication No.: US11459405B2Publication Date: 2022-10-04
- Inventor: Ram Sasisekharan , Kannan Tharakaraman , Vidya Subramanian , Eduardo Fleischer , Andrew Peter Hatas
- Applicant: Massachusetts Institute of Technology
- Applicant Address: US MA Cambridge
- Assignee: Massachusetts Institute of Technology
- Current Assignee: Massachusetts Institute of Technology
- Current Assignee Address: US MA Cambridge
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- International Application: PCT/US2016/068808 WO 20161228
- International Announcement: WO2017/117179 WO 20170706
- Main IPC: C07K16/46
- IPC: C07K16/46 ; C07K16/22 ; C07K16/32 ; C07K16/28
Abstract:
Described herein are mutations in the CH1/CL interface and CH3 constant regions of a bispecific antibody which facilitate heterodimerization and methods for the efficient production of bispecific antibodies. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
Public/Granted literature
- US20190023810A1 BISPECIFIC ANTIBODIES HAVING CONSTANT REGION MUTATIONS AND USES THEREFOR Public/Granted day:2019-01-24
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