Invention Grant
- Patent Title: Recombinant chimeric antigen receptor gene and use thereof
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Application No.: US16193473Application Date: 2018-11-16
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Publication No.: US11459543B2Publication Date: 2022-10-04
- Inventor: Xiulian Sun
- Applicant: YIMING (BEIJING) CELL BIOTECH LTD.
- Applicant Address: CN Beijing
- Assignee: YIMING (BEIJING) CELL BIOTECH LTD.
- Current Assignee: YIMING (BEIJING) CELL BIOTECH LTD.
- Current Assignee Address: CN Beijing
- Agency: Pearl Cohen Zedek Latzer Baratz LLP
- Agent Mark S. Cohen
- Main IPC: C12N5/0783
- IPC: C12N5/0783 ; C12N15/62 ; C07K16/28 ; A61P35/00

Abstract:
The invention provides a recombinant chimeric antigen receptor (CAR) gene, a vector containing the same, a CAR-T cell and a use thereof. The recombinant CAR gene comprises a nucleic acid sequence encoding an antigen-binding portion of a CD30 antibody, a transmembrane portion and a CD137 cytoplasmic functional region and a CD3zeta cytoplasmic functional region linked in any order; also provides a method of treating Hodgkin's lymphoma or anaplastic large cell lymphoma or other CD30-positive tumors using the CAR-T cells of the invention.
Public/Granted literature
- US20190249142A1 RECOMBINANT CHIMERIC ANTIGEN RECEPTOR GENE AND USE THEREOF Public/Granted day:2019-08-15
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