Methods for using transcription-dependent directed evolution of AAV capsids

Invention Grant

US11459558B2 Methods for using transcription-dependent directed evolution of AAV capsids 有权

Patent Title: Methods for using transcription-dependent directed evolution of AAV capsids
Application No.: US17337341

Application Date: 2021-06-02
Publication No.: US11459558B2

Publication Date: 2022-10-04
Inventor: Hiroyuki Nakai , Samuel Huang , Kei Adachi
Applicant: Oregon Health & Science University
Applicant Address: US OR Portland
Assignee: Oregon Health & Science University
Current Assignee: Oregon Health & Science University
Current Assignee Address: US OR Portland
Agency: Wilson Sonsini Goodrich & Rosati
Main IPC: C12N15/11
IPC: C12N15/11 ; C12N7/00 ; C12N15/86

Abstract:

Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods.

Public/Granted literature

Information query

Espacenet

IPC分类:

C	化学；冶金
C12	生物化学；啤酒；烈性酒；果汁酒；醋；微生物学；酶学；突变或遗传工程
C12N	微生物或酶；其组合物；繁殖、保藏或维持微生物；变异或遗传工程；培养基（微生物学的试验介质入C12Q1/00）。
C12N15/00	突变或遗传工程；遗传工程涉及的DNA或RNA，载体（如质粒）或其分离、制备或纯化；所使用的宿主（突变体或遗传工程制备的微生物本身入C12N1/00、C12N5/00、C12N7/00；新的植物入A01H；用组织培养技术再生植物入A01H4/00；新的动物入A01K67/00；含有插入活体细胞的遗传物质以治疗遗传疾病的药剂的应用，基因疗法入A61K48/00，一般肽入C07K）
C12N15/09	.DNA重组技术
C12N15/11	..DNA或RNA片段；其修饰形成（不用于重组技术的DNA或RNA入C07H21/00）