Invention Grant
- Patent Title: Target mediated in situ signal amplification with dual interacting hairpin probes
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Application No.: US16615922Application Date: 2018-05-23
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Publication No.: US11459603B2Publication Date: 2022-10-04
- Inventor: Sanjay Tyagi , Salvatore A. E. Marras
- Applicant: Rutgers, The State University of New Jersey
- Applicant Address: US NJ New Brunswick
- Assignee: Rutgers, The State University of New Jersey
- Current Assignee: Rutgers, The State University of New Jersey
- Current Assignee Address: US NJ New Brunswick
- Agency: Fox Rothschild LLP
- International Application: PCT/US2018/034150 WO 20180523
- International Announcement: WO2018/217905 WO 20181129
- Main IPC: C12Q1/6841
- IPC: C12Q1/6841 ; C12N15/11 ; C12Q1/682 ; C12Q1/6827 ; C12Q1/6876
Abstract:
The present invention relates to the detection of nucleic acids sequences in situ using hybridization probes and generation of amplified hybridization signals, wherein background signal is reduced and sensitivity is increased.
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