A combination default write-blocking system may include a host computer. The host computer may include at least one general storage device storing program instructions for a blocking driver assembly and a host processor configured as the blocking driver assembly while executing the program instructions for the blocking driver assembly. A connection interface device physically separate from the host processor, and the connection interface device is configured to be operatively coupled to the host processor and to a protected storage device physically separate from the general storage device, receive a communication from the blocking driver assembly, and establish communication between the protected storage device and the host processor after receiving the communication from the blocking driver assembly. The blocking driver assembly is further configured to communicate with the connection interface device and conditionally allow a host computer process to alter data stored on the protected storage device.