Methods and apparatus to adapt medical imaging interfaces based on learning are disclosed. An example apparatus includes a use monitor to monitor, in a first session, user actions and medical content data pertaining to operation of a clinical image display, a learning device including a processor to implement a learning network to develop a model for a subsequent session based on the user actions in relationship to a context of the medical content data. The model developed by defining contextual patterns of the user actions based on the context and the medical content data. The learning device is to update, prior to or during a second session subsequent the first session, a user interface based on the model.