Various embodiments provide methods, vehicle computing devices, storage media, and systems for unicast transmission of cellular vehicle-to-everything (C-V2X) Internet Protocol (IP) packets. Various embodiments may enable upper layers in a stack architecture to realize unicast transmission of C-V2X IP packets. In various embodiments, source port and destination IP address pairings may be associated with destination layer 2 (L2) addresses. In various embodiments, a source port indication and destination IP address indication may be added to a unicast C-V2X IP packet, such as a transmission control protocol (TCP) packet, a user datagram protocol (UDP) packet, etc., and the source port and destination IP address indications may be used by a modem to determine the destination L2 address for the unicast C-V2X IP packet.