Invention Grant
- Patent Title: Systems and methods for in vivo dual recombinase-mediated cassette exchange (dRMCE) and disease models thereof
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Application No.: US16071407Application Date: 2016-12-30
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Publication No.: US11466290B2Publication Date: 2022-10-11
- Inventor: Joshua Breunig , Moise Danielpour , Gi Bum Kim
- Applicant: CEDARS-SINAI MEDICAL CENTER
- Applicant Address: US CA Los Angeles
- Assignee: CEDARS-SINAI MEDICAL CENTER
- Current Assignee: CEDARS-SINAI MEDICAL CENTER
- Current Assignee Address: US CA Los Angeles
- Agency: Nixon Peabody LLP
- Agent Linda B. Huber
- International Application: PCT/US2016/069442 WO 20161230
- International Announcement: WO2017/131926 WO 20170803
- Main IPC: C12N15/85
- IPC: C12N15/85 ; A01K67/027 ; A61K48/00 ; A61K49/00 ; C12N9/22 ; C12N15/11
Abstract:
Described herein are donor vectors and systems for use in in vivo dual recombinase-mediated cassette exchange. Also described are animal models for consistent, rigorous, and facile investigation of transgene expression. Further described are methods of screening for therapeutic drugs using these animal models, and methods of treatment.
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