Invention Grant
- Patent Title: Nucleic acid molecule for reduction of PAPD5 and PAPD7 mRNA for treating hepatitis B infection
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Application No.: US16661959Application Date: 2019-10-23
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Publication No.: US11484546B2Publication Date: 2022-11-01
- Inventor: Susanne Kammler , Anaïs Lopez , Henrik Mueller , Søren Ottosen , Lykke Pedersen
- Applicant: HOFFMAN-LA ROCHE INC.
- Applicant Address: US NJ Little Falls
- Assignee: HOFFMAN-LA ROCHE INC.
- Current Assignee: HOFFMAN-LA ROCHE INC.
- Current Assignee Address: US NJ Little Falls
- Agency: Holland & Hart LLP
- Priority: EP17196554 20171016,EP17208056 20171218
- Main IPC: A61K31/7105
- IPC: A61K31/7105 ; C07H21/02 ; A61K31/712 ; C12N15/113 ; A61P31/20
Abstract:
The present invention relates to nucleic acid molecules that are complementary to both PAP associated domain containing 5 (PAPD5) and PAP associated domain containing 7 (PAPD7), leading to inhibition of the expression of both PAPD5 and PAPD7 when using a single nucleic acid molecule. The invention also provides for PAPD5 and PAPD7 specific nucleic acid molecules for use in treating and/or preventing a HBV infection, in particular a chronic HBV infection. Also comprised in the present invention is a pharmaceutical composition for use in the treatment and/or prevention of a HBV infection.
Public/Granted literature
- US20200147123A1 NUCLEIC ACID MOLECULE FOR REDUCTION OF PAPD5 AND PAPD7 mRNA FOR TREATING HEPATITIS B INFECTION Public/Granted day:2020-05-14
Information query
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