Invention Grant
- Patent Title: Membrane-spanning nanopores
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Application No.: US16317085Application Date: 2017-07-14
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Publication No.: US11485995B2Publication Date: 2022-11-01
- Inventor: Stefan Howorka , Genevieve Pugh , Jonathan Richard Burns
- Applicant: UCL BUSINESS LTD
- Applicant Address: GB London
- Assignee: UCL BUSINESS LTD
- Current Assignee: UCL BUSINESS LTD
- Current Assignee Address: GB London
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Nicole D. Kling
- Priority: GB1612458 20160714
- International Application: PCT/GB2017/052089 WO 20170714
- International Announcement: WO2018/011603 WO 20180118
- Main IPC: C12Q1/6825
- IPC: C12Q1/6825

Abstract:
A membrane-spanning nanopore is provided that comprises: i. at least one scaffold polynucleotide strand; ii. a plurality of staple polynucleotide strands; and iii. at least one hydrophobically-modified polynucleotide strand, wherein the at least one hydrophobically-modified polynucleotide strand comprises a polynucleotide strand and a hydrophobic moiety; wherein each of the plurality of staple polynucleotide strands hybridises to the at least one scaffold polynucleotide strand to form the three-dimensional structure of the membrane-spanning nanopore, and wherein the at least one hydrophobically-modified polynucleotide strand hybridises to a portion of the at least one scaffold polynucleotide strand, the membrane-spanning nanopore defining a central channel with a minimum internal width of at least about 5 nm. Membranes comprising the membrane-spanning nanopore and applications of those membranes are also provided.
Public/Granted literature
- US20190309350A1 MEMBRANE-SPANNING NANOPORES Public/Granted day:2019-10-10
Information query
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