A deskew circuit for a differential signal is provided. A first common mode voltage generating circuit generates a first common mode voltage signal according to first and second differential input signals. A voltage buffer circuit is coupled to the first common mode voltage generating circuit and has an input impedance higher than a preset value, and buffers the first common mode voltage signal and the first and second differential input signals to generate a second common mode voltage signal, a third differential input signal, and a fourth differential input signal. A second common mode voltage generating circuit is coupled to the voltage buffer circuit and generates a third common mode voltage signal according to the third and fourth differential input signals. An output circuit generates a deskew output signal according to the third and fourth differential input signals and the second and third common mode voltage signals.