Invention Grant
- Patent Title: Optimized AGA genes and expression cassettes and their use
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Application No.: US16761290Application Date: 2018-03-22
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Publication No.: US11491241B2Publication Date: 2022-11-08
- Inventor: Steven James Gray
- Applicant: The University of North Carolina at Chapel Hill
- Applicant Address: US NC Chapel Hill
- Assignee: The University of North Carolina at Chapel Hill
- Current Assignee: The University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Chapel Hill
- Agency: Myers Bigel, P.A.
- International Application: PCT/US2018/023727 WO 20180322
- International Announcement: WO2019/094061 WO 20190516
- Main IPC: C12N15/11
- IPC: C12N15/11 ; A61K48/00 ; C12N15/86
Abstract:
This invention relates to polynucleotides comprising optimized aspartylglucosaminidase (AGA) open reading frames and vectors and cells comprising the same. The invention further relates to methods of using the same for delivery of the open reading frame to a cell or a subject and methods for treating aspartylglucosaminuria (AGU) in a subject.
Public/Granted literature
- US20210330811A1 OPTIMIZED AGA GENES AND EXPRESSION CASSETTES AND THEIR USE Public/Granted day:2021-10-28
Information query
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