Invention Grant
- Patent Title: Genetically induced nephron progenitors
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Application No.: US16616229Application Date: 2018-05-24
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Publication No.: US11492644B2Publication Date: 2022-11-08
- Inventor: Melissa Little , Jessica Vanslambrouck , Lauren Woodard , Matthew Wilson
- Applicant: MURDOCH CHILDRENS RESEARCH INSTITUTE , VANDERBILT UNIVERSITY , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
- Applicant Address: AU Victoria; US TN Nashville; US DC Washington
- Assignee: MURDOCH CHILDRENS RESEARCH INSTITUTE,VANDERBILT UNIVERSITY,THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
- Current Assignee: MURDOCH CHILDRENS RESEARCH INSTITUTE,VANDERBILT UNIVERSITY,THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
- Current Assignee Address: AU Victoria; US TN Nashville; US DC Washington
- Agency: Meunier Carlin & Curfman LLC
- International Application: PCT/AU2018/050502 WO 20180524
- International Announcement: WO2018/213886 WO 20181129
- Main IPC: C12N15/90
- IPC: C12N15/90 ; C12N5/071 ; C12N15/85
Abstract:
Expression of exogenous SNAI2, EYA1 and SIX1 genes in a cell, tissue or organ not normally having nephron progenitor activity, induces or re-programs that cell to have or subsequently develop nephron progenitor activity. Nephron progenitors induced 5 by expression of SNAI2, EYA1 and SIX1 may be used for the production of nephron cells and tissues that are useful in treatment of kidney disorders, kidney regeneration, kidney transplantation, bioprinting and nephrotoxocity testing.
Public/Granted literature
- US20200157572A1 GENETICALLY INDUCED NEPHRON PROGENITORS Public/Granted day:2020-05-21
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