Invention Grant
- Patent Title: Composition and use of Cas protein inhibitors
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Application No.: US17272252Application Date: 2019-08-29
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Publication No.: US11492645B2Publication Date: 2022-11-08
- Inventor: Jia Liu , Biao Jiang , Peixiang Ma , Guang Yang
- Applicant: ShanghaiTech University
- Applicant Address: CN Shanghai
- Assignee: ShanghaiTech University
- Current Assignee: ShanghaiTech University
- Current Assignee Address: CN Shanghai
- Agency: Sheppard Mullin Richter & Hampton LLP
- Priority: WOPCT/CN2018/102908 20180829
- International Application: PCT/CN2019/103203 WO 20190829
- International Announcement: WO2020/043148 WO 20200305
- Main IPC: C12N15/63
- IPC: C12N15/63 ; A61K31/70 ; C12N15/90 ; A61K31/7088 ; A61K38/16 ; A61K38/46 ; A61K38/50 ; C12N7/00 ; A01K67/00

Abstract:
Provided are amino acid sequences capable of binding to and inhibiting a Cas protein's ability to bind to a nucleic acid molecule, thereby inhibiting the Cas protein's function in genome editing. Such Cas protein inhibitors, which can be comprised of a major coat protein (G8P), an extracellular region of the G8P (G8PEX), or a biological equivalent, are useful in improving the specificity of Cas protein-based genome editing procedures.
Public/Granted literature
- US20210317480A1 COMPOSITION AND USE OF CAS PROTEIN INHIBITORS Public/Granted day:2021-10-14
Information query
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