Invention Grant
- Patent Title: Compositions and methods for targeting cancer-specific sequence variations
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Application No.: US15298895Application Date: 2016-10-20
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Publication No.: US11492670B2Publication Date: 2022-11-08
- Inventor: William C. Hahn , Andrew Aguirre , April Cook , Glenn Cowley , Robin Meyers , David E. Root , Aviad Tsherniak , Barbara Weir , Francisca Vazquez
- Applicant: THE BROAD INSTITUTE, INC. , DANA-FARBER CANCER INSTITUTE, INC. , INSTITUTO CARLOS SLIM DE LA SALUD, A.C.
- Applicant Address: US MA Cambridge; US MA Boston; MX Mexico City
- Assignee: THE BROAD INSTITUTE, INC.,DANA-FARBER CANCER INSTITUTE, INC.,INSTITUTO CARLOS SLIM DE LA SALUD, A.C.
- Current Assignee: THE BROAD INSTITUTE, INC.,DANA-FARBER CANCER INSTITUTE, INC.,INSTITUTO CARLOS SLIM DE LA SALUD, A.C.
- Current Assignee Address: US MA Cambridge; US MA Boston; MX Mexico City
- Agency: Withers Bergman LLP
- Agent Christopher R. Cowles
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07K1/00 ; C12Q1/6886 ; A61K38/46 ; A61K45/06 ; C12N9/22 ; C12N9/96 ; C12N15/113 ; A61K48/00 ; B82Y5/00

Abstract:
The present invention relates to compositions and methods for targeting cancer-specific DNA sequences, such as copy number amplifications and other types of cancer-specific sequence variations, such as cancer-specific polymorphisms, insertions, or deletions. The present invention provides hereto sequence-specific DNA targeting agents targeting a sequence within the amplified DNA region or a sequence otherwise specific for a cancer cell compared to a non-cancer cell. The invention further relates to methods for treating cancer, comprising administering such sequence-specific DNA targeting agents. The invention further relates to methods for preparing sequence-specific DNA targeting agent, as well as screening methods using the DNA targeting agents.
Public/Granted literature
- US20170114413A1 COMPOSITIONS AND METHODS FOR TARGETING CANCER-SPECIFIC SEQUENCE VARIATIONS Public/Granted day:2017-04-27
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