Invention Grant
- Patent Title: Methods and systems for determining ancestral relatedness
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Application No.: US17556055Application Date: 2022-01-06
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Publication No.: US11501851B2Publication Date: 2022-11-15
- Inventor: Aaron J. Sams , Samuel H. Vohr , Adam S. Gardner , Matt Barton , Ryan Boyko , Adam R. Boyko
- Applicant: Embark Veterinary, Inc.
- Applicant Address: US MA Boston
- Assignee: Embark Veterinary, Inc.
- Current Assignee: Embark Veterinary, Inc.
- Current Assignee Address: US MA Boston
- Agency: Wilson Sonsini Goodrich & Rosati
- Main IPC: G16B20/40
- IPC: G16B20/40 ; G16B20/20

Abstract:
The present disclosure provides methods of estimating a degree of ancestral relatedness between individuals. In an aspect, a method comprises receiving haplotype data comprising genetic markers shared among a population of individuals; dividing the haplotype data into segments based on the genetic markers; for each of the population of test individuals: (i) based on the genetic markers, matching segments of the haplotype data that are identical-by-descent between two individuals, (ii) for each of the matched segments: dividing the matched segment into discrete genomic intervals, scoring each of the discrete genomic intervals based on a degree of matching within or between the individuals, correcting the scores for consistency, and (iii) calculating a weighted sum over the discrete genomic intervals of the matched segment, based on the corrected scores and assigned weights; and (d) estimating the degree of ancestral relatedness between the individuals based on the weighted sums of the matched segments.
Public/Granted literature
- US20220122693A1 METHODS AND SYSTEMS FOR DETERMINING ANCESTRAL RELATEDNESS Public/Granted day:2022-04-21
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