A method of producing enriched 47Sc comprises irradiating a V structure comprising 51V with at least one incident photon beam having an endpoint energy within a range of from about 14 MeV to about 44 MeV to convert at least some of the 51V to 47Sc and form a 47Sc-containing structure. The 47Sc of the 47Sc-containing structure is separated from additional components of the 47Sc-containing structure using a chromatography process. Systems and apparatuses for producing enriched 47Sc are also described.