Selecting audio noise reduction models for noise suppression in an information handling system (IHS), including performing calibration and configuration of an audio noise reduction selection model, including: identifying contextual data associated with contextual inputs to the IHS; training, based on the contextual data, the audio noise reduction selection model, including generating a configuration policy including configuration rules, the configuration rules for performing actions for selection of a combination of audio noise reduction models to reduce combinations of noise sources associated with the IHS; performing steady-state monitoring of the IHS, including: monitoring the contextual inputs of the IHS, and in response, accessing the audio noise reduction selection model, identifying configuration rules based on the monitored contextual inputs, applying the configuration rules to select a particular combination of audio noise reduction models, applying particular combination of audio noise reduction models to reduce a particular combination of noise sources associated with the IHS.