A system for serial communication may include a first device and a plurality of devices on a series connection. The first device may have a master circuit and the plurality devices may have a slave circuit. The master circuit may enable the first device to communicate with the plurality devices having the slave circuit on the series connection. The master circuit may enable the first device to send a command frame on the series connection. The command frame may include an execution mode command and a plurality of commands. The second devices may execute the commands within the command frame at or after the end of the command frame based on the execution mode command indicating a synchronous mode of command execution; and may execute the commands within the command frame at the ends of individual ones of the commands based on the execution mode command indicating a non-synchronous mode of command execution.