Invention Grant
- Patent Title: Delayed release drug formulation
-
Application No.: US15612065Application Date: 2017-06-02
-
Publication No.: US11517534B2Publication Date: 2022-12-06
- Inventor: Felipe Josè Oliveira Varum , Roberto Carlos Bravo González , Thomas Buser , Abdul Waseh Basit , Ana Cristina Freire
- Applicant: Tillotts Pharma AG
- Applicant Address: CH Rheinfelden
- Assignee: Tillotts Pharma AG
- Current Assignee: Tillotts Pharma AG
- Current Assignee Address: CH Rheinfelden
- Agency: Grüneberg and Myers PLLC
- Priority: EP12166110 20120430
- Main IPC: A61K9/28
- IPC: A61K9/28 ; A61K31/196 ; A61K31/606 ; A61K31/616 ; A61K47/32 ; A61K47/36 ; A61K47/38 ; A61K9/00 ; A61K9/20

Abstract:
In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said soluble polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralised, and a non-ionic polymer, provided that, where said soluble polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base.
Public/Granted literature
- US20170266117A1 DELAYED RELEASE DRUG FORMULATION Public/Granted day:2017-09-21
Information query