Invention Grant
- Patent Title: Fluorinated bile acid derivatives
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Application No.: US17262915Application Date: 2019-07-30
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Publication No.: US11517577B2Publication Date: 2022-12-06
- Inventor: Alexander Charles Weymouth-Wilson , Gemma Packer , Bruno Jan Pol Linclau , Dannielle Kydd-Sinclair , Kimberly Ann Watson
- Applicant: NZP UK LIMITED , THE UNIVERSITY OF SOUTHAMPTON
- Applicant Address: GB Bristol; GB Southampton
- Assignee: NZP UK LIMITED,THE UNIVERSITY OF SOUTHAMPTON
- Current Assignee: NZP UK LIMITED,THE UNIVERSITY OF SOUTHAMPTON
- Current Assignee Address: GB Bristol; GB Southampton
- Agency: Morgan, Lewis & Bockius, LLP
- Priority: GB1812382.8 20180730
- International Application: PCT/GB2019/052127 WO 20190730
- International Announcement: WO2020/025942 WO 20200206
- Main IPC: A61K31/64
- IPC: A61K31/64 ; A61P1/16 ; A61K31/575 ; C07J41/00

Abstract:
The invention relates to compounds of general formula (I): wherein R2a, R2b, R3a, R3b, R5, Y and R7 are as defined herein are selective agonists at the FXR receptor and are useful for the treatment or prevention of diseases and conditions including nonalcoholic steatohepatitis (NASH); primary biliary cirrhosis; primary sclerosing cholangitis; biliary atresia; cholestatic liver disease; hepatitis C infection; alcoholic liver disease; fibrosis; and liver damage arising from fibrosis.
Public/Granted literature
- US20210299148A1 FLUORINATED BILE ACID DERIVATIVES Public/Granted day:2021-09-30
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