Examples herein provide a syringe comprising a fluid reservoir and a male connector comprising a fluid flow channel in fluid communication with the fluid reservoir. The male connector including a male luer having a tapered sealing surface configured to mate with a female tapered surface of a female connector to form a substantially fluid-tight seal. The male luer has a distal tip with a recess defined by a recess surface that is distal to the tapered sealing surface. A water-soluble antimicrobial composition is disposed on the recess surface. The male luer is configured such that, when the male connector is mated with a female connector to form a substantially fluid-tight seal, a cavity is formed between the female tapered surface and the recess surface.