Invention Grant
- Patent Title: Methods of enhancing engraftment activity of hematopoietic stem cells
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Application No.: US16481294Application Date: 2018-01-26
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Publication No.: US11518981B2Publication Date: 2022-12-06
- Inventor: Punam Malik
- Applicant: CHILDREN'S HOSPITAL MEDICAL CENTER
- Applicant Address: US OH Cincinnati
- Assignee: CHILDREN'S HOSPITAL MEDICAL CENTER
- Current Assignee: CHILDREN'S HOSPITAL MEDICAL CENTER
- Current Assignee Address: US OH Cincinnati
- Agency: McDermott Will & Emery
- International Application: PCT/US2018/015547 WO 20180126
- International Announcement: WO2018/140791 WO 20180802
- Main IPC: C12N5/0789
- IPC: C12N5/0789 ; A61K35/28
Abstract:
Provided herein are methods for preparing hematopoietic stem cells (HSCs) having enhanced engraftment activity, for example, by contacting HSCs in the presence of a p38 MAPK inhibitor and a HIF-1a stabilizer.
Public/Granted literature
- US20190338249A1 METHODS OF ENHANCING ENGRAFTMENT ACTIVITY OF HEMATOPOIETIC STEM CELLS Public/Granted day:2019-11-07
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