Invention Grant
- Patent Title: Tumor-navigating, self-eradicating, trail-armed salmonella for precision cancer therapy
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Application No.: US17433222Application Date: 2020-02-20
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Publication No.: US11519007B2Publication Date: 2022-12-06
- Inventor: Wei Kong
- Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
- Applicant Address: US AZ Scottsdale
- Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
- Current Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
- Current Assignee Address: US AZ Scottsdale
- Agency: Quarles & Brady, LLP
- International Application: PCT/US2020/019111 WO 20200220
- International Announcement: WO2020/172462 WO 20200827
- Main IPC: C12N15/87
- IPC: C12N15/87 ; A61P35/00 ; A61K35/74 ; C12R1/42
Abstract:
The present disclosure relates to genetically modified strains of Salmonella, engineered to be tumor navigating, self-eradicating, and armed with TRAIL to trigger tumor cell apoptosis. Also provided herein are methods of producing and methods of using such genetically modified Salmonella strains to treat cancer.
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