Invention Grant
- Patent Title: Complexes for gene deletion and editing
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Application No.: US16463646Application Date: 2018-01-08
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Publication No.: US11519009B2Publication Date: 2022-12-06
- Inventor: Michael P. Czech , Yuefei Shen
- Applicant: UNIVERSITY OF MASSACHUSETTS
- Applicant Address: US MA Boston
- Assignee: UNIVERSITY OF MASSACHUSETTS
- Current Assignee: UNIVERSITY OF MASSACHUSETTS
- Current Assignee Address: US MA Boston
- Agency: Lathrop GPM LLP
- Agent James H. Velema, Esq.; Michael Spellberg
- International Application: PCT/US2018/012764 WO 20180108
- International Announcement: WO2018/129440 WO 20180712
- Main IPC: C12N15/90
- IPC: C12N15/90 ; C12N15/113 ; C12N9/22 ; C12N9/96 ; A61K47/64 ; A61K47/54 ; A61P3/04 ; A01K67/027 ; A61K9/00 ; C07K7/06 ; C07K7/08 ; C07K14/00 ; C07K14/47 ; C12N5/077
Abstract:
Complexes comprising a nucleic acid-guided endonuclease, a sequence-specific targeting nucleic acid and an amphipathic helical peptide are provided. Compositions and methods for delivery of complexes comprising a nucleic acid-guided endonuclease, a sequence-specific targeting nucleic acid and an amphipathic helical peptide to mammals for both research and therapeutic use are provided. Methods of treating or reducing one or more symptoms of type 2 diabetes, prediabetes and/or gestational diabetes are provided.
Public/Granted literature
- US20190316156A1 COMPLEXES FOR GENE DELETION AND EDITING Public/Granted day:2019-10-17
Information query
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