Aspects of the disclosure relate to use of supervised, unsupervised, semi-supervised, or reinforcement-based machine learning algorithm(s) to perform pattern recognition and/or cluster detection on historical transactional data in order to predict events that may occur in the future and are candidates for automated delivery of items from a source to a customer in a contactless manner, via a secure delivery device, to minimize health risk(s) to the customer. The items may be securely delivered in an automated manner such as, for example, by use of a drone or autonomous vehicle, which may have advanced sensors to facilitate various aspects of the delivery. The items may be contained in a secure carrier coupled to the delivery device and may be unlocked locally or remotely using mechanical or digital means. Novel logical systems, architectures, machines, platforms, delivery devices and components thereof, and methods are disclosed.