A mechanism is provided in a data processing system to implement a personalized patient engagement engine. The personalized patient engagement engine develops a set of models for a plurality of behavioral phenotypes based on anonymized unstructured and structured patient-care management records for a plurality of patients over a period of time; matches a given patient to a behavioral phenotype; estimates a propensity of positive and/or negative behavioral responses of each of a plurality of targeted behaviors; dynamically updates personalized intervention effectiveness rankings in context for care manager and patient decision-making based on what has been shown to lead to positive responses for individuals with a similar behavioral profile; generates an intervention recommendation for the given patient based on the personalized intervention effectiveness rankings relative to the patient given an assigned goal and an individual intervention effect estimation; and provides the intervention recommendation to the care manager.