A driving method of display panel and a display device are provided, the driving method includes: taking a time duration of scanning at least two adjacent columns of pixel units as a driving period, a common electrodes of sub-pixels in the pixel units of a preset row are driven by different preset voltages in the current driving period, and the sub-pixels does not need to be driven by doubling the metal wiring and the driving device, thus to achieve the purpose of saving cost; and when the preset voltage is a positive or negative polarity driving voltage, the high voltage sub-pixel and the low-voltage sub-pixel in the pixel unit are driven by a preset driving mode.