The present disclosure relates to highly secure, high speed encryption methodologies suitable for applications such as media streaming, streamed virtual private network (VPN) services, large file transfers and the like. For example, encryption methodologies as described herein can provide stream ciphers for streaming data from, for example, a media service provider to a plurality of users. Certain configurations provide wire speed single use encryption. The methodologies as described herein are suited for use with blockchain (e.g. Bitcoin) technologies.