The present disclosure relates to an organic light emitting diode display panel and a method of manufacturing the organic light emitting diode display panel. A display panel, including: a plurality of first light emitting layers arranged in an array in a first direction and a second direction; and a pixel defining layer including a plurality of first openings, wherein each first opening has a reduced size in the first direction, so that the corresponding first light emitting zone defined by the first opening has a first misalignment tolerance range in the first direction, and has a second misalignment tolerance range in the second direction, the corresponding first light emitting zone is allowed to shift in the first direction within the first misalignment tolerance range without overlapping the shaded region of the corresponding first light emitting layer.