A method and a device for transmitting and receiving a signal in a wireless communication system, according to one embodiment of the present invention, comprise: receiving downlink control information (DCI) for scheduling a physical uplink shared channel (PUSCH); and transmitting the PUSCH on the basis of the DCI. The PUSCH is transmitted in a certain number of resource blocks (RB), and the certain number of RBs may be (i) at most the number of RBs allocated by the DCI, and (ii) the greatest number that is a multiple of 2, 3, and/or 5.