- Patent Title: Compounds and their use as therapeutically active substances in the treatment and/or reducing signs or symptoms of diseases involving the retinal pigment epithelium
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Application No.: US17065795Application Date: 2020-10-08
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Publication No.: US11541039B2Publication Date: 2023-01-03
- Inventor: Matthias Steger , Alex Mueller , Mauro Marigo
- Applicant: ENDOGENA THERAPEUTICS, INC.
- Applicant Address: US CA San Francisco
- Assignee: ENDOGENA THERAPEUTICS, INC.
- Current Assignee: ENDOGENA THERAPEUTICS, INC.
- Current Assignee Address: US CA San Francisco
- Agency: Oliff PLC
- Main IPC: A61K31/423
- IPC: A61K31/423 ; A61P27/02 ; A61K31/422 ; C07D413/04 ; C07D413/14

Abstract:
A method of treating and/or preventing disease wherein retinal pigment epithelium, including administering compound of formula (I) or pharmaceutically acceptable salt, racemic mixture, corresponding enantiomer or, if applicable, corresponding diastereomer, wherein: X is either NH or O, R11, R12 and R13 are independently selected from consisting hydrogen group, fluoro, chloro, trifluoromethyl, methyl and difluoromethoxy, A is selected from consisting residue group of formula (II)-(VII) or (VIII) “*” denotes point of attachment to molecule remainder, and R2, R3, R4, R5, R2I, R3I, R4I, R5I, R2II, R3II, R4II, R5II, R2III, R3III, R4III, R5III, R2IV, R3IV, R4IV, R5IV, R2V, R3V, R4V, R5V, R2VI, R3VI, R4VI and R5VI are independently selected from hydrogen consisting group, linear or branched alkyl having 1-3 carbon atoms, fluoro, chloro, bromo, methoxy, ethoxy, propoxy, trifluoromethyl, 2,2,2-trifluoroethyl and difluoromethoxy and R6 is selected from hydrogen consisting group, linear or branched alkyl having 1-3 carbon atoms, trifluoromethyl, and 2,2,2-trifluoroethyl.
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