Invention Grant
- Patent Title: Compositions and methods for treating CDK4/6-mediated cancer
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Application No.: US16467888Application Date: 2017-12-07
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Publication No.: US11541051B2Publication Date: 2023-01-03
- Inventor: Jian Jin , Xiaobao Yang , Jing Liu , Yan Xiong , Poulikos Poulikakos , Zoi Karoulia , Xuewei Wu , Tamer Ahmed
- Applicant: Icahn School of Medicine at Mount Sinai
- Applicant Address: US NY New York
- Assignee: Icahn School of Medicine at Mount Sinai
- Current Assignee: Icahn School of Medicine at Mount Sinai
- Current Assignee Address: US NY New York
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2017/065027 WO 20171207
- International Announcement: WO2018/106870 WO 20180614
- Main IPC: A61K31/506
- IPC: A61K31/506 ; A61K31/519 ; A61K45/06 ; A61K47/55 ; A61P35/00 ; C07D471/04
Abstract:
Methods for designing heterobifunctional small molecules which selectively degrade/disrupt CDK4/6 and compositions and methods of using such degraders/disruptors to treat CDK4/6-mediated cancer are provided.
Public/Granted literature
- US11285150B2 Compositions and methods for treating CDK4/6-mediated cancer Public/Granted day:2022-03-29
Information query
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