Methods and compositions for increasing sexual desire and pleasure in a mammal are provided. In at least one embodiment, a composition comprising at least (1) damiana (Turnera diffusa) extract, (2) theacrine, (3) ginseng, (4) vitamin C, (5) vitamin B12, (6) saffron, (7) potassium nitrate is provided as an oral dosage unit. The claimed composition provides improved sexual desire and pleasure in female mammals.