A vehicle door assembly includes a door structure, an interior latch handle a panel and an interference member. The interior latch handle is installed to an inboard area of an inner door panel of the door structure. The interior latch handle has a housing and a release lever supported to the housing for pivotal movement. The panel is fixed to the inner door panel. The interference member is fixed to the panel and extends toward the release lever. With the door structure in a non-deformed state the interference member is spaced apart from the release lever. With the door structure in a deformed state in response to an impact event proximate a central area of the door structure, the panel can deformed and moves the interference member toward one end of the release lever preventing movement of the release lever to an door opening orientation.