Provided is a reusable packing box, comprising a protective box body (1) enclosed by a bottom surface and a plurality of slanted side walls, and an elastic inflatable layer (3) adhered to an inner side of the protective box body, wherein the elastic inflatable layer (3) is provided with a vent (4), and the vent (4) is embedded in the protective box body (1). The reusable packing box can reuse a packaging material and a filling material, thereby reducing the phenomenon of waste, and improving the management efficiency.