Invention Grant
- Patent Title: Preparative process
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Application No.: US16980210Application Date: 2019-03-08
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Publication No.: US11542245B2Publication Date: 2023-01-03
- Inventor: Julian Egger , Daniel Goetz , Michal Sowa
- Applicant: Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft
- Applicant Address: DE Leverkusen; DE Berlin
- Assignee: Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft
- Current Assignee: Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft
- Current Assignee Address: DE Leverkusen; DE Berlin
- Agency: McBee Moore & Vanik IP, LLC
- Priority: EP18161983 20180315
- International Application: PCT/EP2019/055815 WO 20190308
- International Announcement: WO2019/175043 WO 20190919
- Main IPC: C07D401/10
- IPC: C07D401/10

Abstract:
The present invention relates to a process for preparing 4-{[(2S)-2-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-5-methoxy-2-oxopyridin-1(2H)-yl}butanoyl]amino}-2-fluorobenzamide (I) or 4-({(2S)-2-[4-{5-chloro-2-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}-5-methoxy-2-oxopyridin-1(2H)-yl]butanoyl}amino)-2-fluorobenzamide (II) from 2,5-dimethoxypyridine (III), 1-(2-bromo-4-chlorophenyl)-4-chloro-1H-1,2,3-triazole (X-Cl) or 1-(2-bromo-4-chlorophenyl)-4-(trifluoromethyl)-1H-1,2,3-triazole (X-CF3), 4-amino-2-fluorbenzamide (XIII) and (2R)-2-aminobutanoic acid (XVII).
Public/Granted literature
- US20210017152A1 PREPARATIVE PROCESS Public/Granted day:2021-01-21
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