Invention Grant
- Patent Title: Amide compound having bet proteolysis-inducing action and medicinal application thereof
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Application No.: US17256633Application Date: 2019-07-04
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Publication No.: US11542273B2Publication Date: 2023-01-03
- Inventor: Ryuta Yamazaki , Tatsuya Ibuki , Yuichi Sawaguchi , Kiyomi Ohba , Maiko Hamada , Yasuki Niwa , Yuko Ishida , Hideto Maruyama , Shiki Matsuki , Minoru Tanaka
- Applicant: MITSUBISHI TANABE PHARMA CORPORATION
- Applicant Address: JP Osaka
- Assignee: MITSUBISHI TANABE PHARMA CORPORATION
- Current Assignee: MITSUBISHI TANABE PHARMA CORPORATION
- Current Assignee Address: JP Osaka
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: JPJP2018-127896 20180704
- International Application: PCT/JP2019/026553 WO 20190704
- International Announcement: WO2020/009176 WO 20200109
- Main IPC: C07D495/14
- IPC: C07D495/14 ; A61P35/02
Abstract:
Provided are a compound superior in a cytotoxic action on cancer cells, an action inducing degradation of BET protein in cancer cells, and an inhibitory action on the binding of BET protein and acetylated histone, and useful as an anticancer agent, a BET protein degradation inducer or a BET protein inhibitor. A compound represented by the following formula (I) wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof.
Public/Granted literature
- US20210284654A1 AMIDE COMPOUND HAVING BET PROTEOLYSIS-INDUCING ACTION AND MEDICINAL APPLICATION THEREOF Public/Granted day:2021-09-16
Information query
