Invention Grant
- Patent Title: Substituted imidazolidin-2-one derivatives as PRMT5 inhibitors
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Application No.: US16982800Application Date: 2019-03-20
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Publication No.: US11542275B2Publication Date: 2023-01-03
- Inventor: Dinesh Chikkanna , Sunil Kumar Panigrahi , Srinivasa Raju Sammeta
- Applicant: Aurigene Discovery Technologies Limited
- Applicant Address: IN Bangalore
- Assignee: Aurigene Discovery Technologies Limited
- Current Assignee: Aurigene Discovery Technologies Limited
- Current Assignee Address: IN Bangalore
- Agency: Dennemeyer & Associates
- Agent Steven M. Shape
- Priority: IN201841010656 20180322
- International Application: PCT/IB2019/052252 WO 20190320
- International Announcement: WO2019/180631 WO 20190926
- Main IPC: C07D498/08
- IPC: C07D498/08 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D471/08 ; C07D487/04 ; C07D491/107 ; C07D493/08 ; C07D495/04
Abstract:
The present invention relates to substituted imidazolidin-2-one derivatives of formula (I) or pharmaceutically acceptable salts thereof. The present invention further provides the methods of preparation of compound of formula (I) and utility as PRMT5 inhibitors. The compounds are useful as medicaments in the treatment of conditions and disorders mediated by PRMT5, such as cancer, metabolic disorders, inflammation, autoimmune disease and hemoglobinopathies.
Public/Granted literature
- US20210002298A1 SUBSTITUTED IMIDAZOLIDIN-2-ONE DERIVATIVES AS PRMT5 INHIBITORS Public/Granted day:2021-01-07
Information query
